ABSTRACT
The review analyzes data on the course and outcomes of axial spondyloarthritis (axSpA) accumulated over the previous 2.5 years of the COVID-19 pandemic. The issues of clinical and immunological efficacy of vaccination against COVID-19 in this disease are considered. It was noted that the presence of axSpA, as well as treatment with tumor necrosis factor-α inhibitors and non-steroidal anti-inflammatory drugs, did not significantly increase the risk of COVID-19 infection and did not worsen its outcomes, apart from an increase in the incidence of venous thromboembolism. At the same time, it is assumed that anticytokine therapy for SpA may protect against severe COVID-19 course. The data presented suggest that the benefits of vaccination in SpA far outweigh the potential harms associated with the development of adverse events. It has been shown that in patients with SpA, vaccination does not affect the activity of the inflammatory process, and biologic disease modifying antirheumatic drugs have almost no significant effect on the post-vaccination response. © 2023, Ima-Press Publishing House. All rights reserved.
ABSTRACT
The review analyzes data on the course and outcomes of axial spondyloarthritis (axSpA) accumulated over the previous 2.5 years of the COVID-19 pandemic. The issues of clinical and immunological efficacy of vaccination against COVID-19 in this disease are considered. It was noted that the presence of axSpA, as well as treatment with tumor necrosis factor-α inhibitors and non-steroidal anti-inflammatory drugs, did not significantly increase the risk of COVID-19 infection and did not worsen its outcomes, apart from an increase in the incidence of venous thromboembolism. At the same time, it is assumed that anticytokine therapy for SpA may protect against severe COVID-19 course. The data presented suggest that the benefits of vaccination in SpA far outweigh the potential harms associated with the development of adverse events. It has been shown that in patients with SpA, vaccination does not affect the activity of the inflammatory process, and biologic disease modifying antirheumatic drugs have almost no significant effect on the post-vaccination response. © 2023, Ima-Press Publishing House. All rights reserved.
ABSTRACT
The 2019 coronavirus disease pandemic (COVID-19) is particularly challenging not only for doctors, but also for patients with inflammatory diseases, including spondyloarthritis. Although a large number of studies have been conducted over the past 2 years on the effect of COVID-19 on patients with rheumatic diseases, however, the conclusions from them are not always unambiguous. Given the growing number of cases of COVID-19 infection worldwide, there is a need to study the impact of individual diseases on its outcomes. The results of the study of COVID-19 in spondyloarthritis are limited to isolated reports of cases of the disease. Moreover, there is practically no literature devoted to the outcomes of COVID-19 exclusively in patients with axial spondyloarthritis. However, over the past few months, two large studies have been published, in total, analyzing the outcomes of infection with SARS-CoV-2 in more than 14,000 patients with spondyloarthritis. The article discusses the results of these studies, the result of which is the conclusion that the presented data should convince both patients and doctors that axial spondyloarthritis and the therapy carried out for its treatment does not increase the risk of infection and does not aggravate the outcomes of COVID-19.
ABSTRACT
The novel coronavirus infection COVID-19 (SARS-CoV-2) is now known to cause a variety of extrapulmonary complications, including cardiovascular, neurological and dermatological complications, many of which occur or last several weeks after infection. We present a clinical case of a patient who first developed symptoms of ankylosing spondylitis 2 weeks after recovering from COVID-19. The patient was prescribed therapy in accordance with international and Russian recommendations for the management of patients with ankylosing spondylitis with a positive effect in the form of absence arthritis, enthesitis and reducing the inflammatory back pain.